The series focuses on a trio made up of the alien princess Ilana, the rebellious soldier Lance, and the robot Octus; the three are able to combine to create the titular Sym-Bionic Titan. A preview of the series was first shown at the 2009 San Diego Comic-Con International, and further details were revealed at Cartoon Network's 2010 Upfront. The series premiered on September 17, 2010, and ended on April 9, 2011. The series is rated TV-PG-V.
Cartoon Network initially ordered 20 episodes; Tartakovsky had hoped to expand on that, but the series was not renewed for another season, as the show "did not have any toys connected to it."
On October 7, 2012, reruns of Sym-Bionic Titan began airing on Adult Swim's Toonami block.
Billed as "an exciting hybrid of high school drama and giant robot battles", Sym-Bionic Titan features "the adventures of three beings from the planet Galaluna who crash-land on Earth while attempting to escape their war-torn world." The series follows the lives of Ilana, Lance, and Octus, two alien teens and a robot in the form of humanoids who arrive on Earth, an "identical" planet to Galaluna, while fleeing an evil general who has taken over their home planet with the help of monstrous creatures called Mutraddi.
The three main characters include Ilana, princess of the royal family; Lance, a rebellious but capable soldier; and Octus, a bio-cybernetic robot, all of whom must now blend into everyday life in Sherman, Illinois. Posing as high school students, Lance and Octus work to conceal Princess Ilana from General Modula and his hideous space mutants sent to kill the sole heir of Galaluna. When called into battle, the Galalunans are outfitted with individual armor that provides more than ample protection. It is when the gravest of danger appears that Octus activates the sym-bionic defense program and he, Ilana, and Lance unite "Heart, Body and Mind" and come together to form the spectacular cyber-giant Sym-Bionic Titan.